リガンド









曖昧さ回避
 この項目では、ある物質に対して特異的に結合する物質について説明しています。錯体化学における配位子については「配位子」をご覧ください。


リガンド（ligand; ライガンド）とは、特定の受容体（receptor; レセプター）に特異的に結合する物質のことである。[1]


リガンドが対象物質と結合する部位は決まっており、選択的または特異的に高い親和性を発揮する。例えば、酵素タンパク質とその基質、ホルモンや神経伝達物質などのシグナル物質とその受容体などが顕著な例である。リガンドの代わりにはたらく薬物がアゴニスト、リガンドのはたらきを弱める薬物はアンタゴニストである。




特にタンパク質と特異的に結合するリガンドは、微量であっても生体に対して非常に大きな影響を与える。
そのため薬学や分子生物学の分野では重要な研究対象になっている。



脚注


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  1. ^ “リガンド (Ligand)”. PharmaDesign, Inc.. 2016年2月1日閲覧。




関連項目



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